Отправить статью по E-mail Synthesis and Antidepressant Properties of 2-[3-Methyl-7-(Thietanyl-3)-1-Ethylxanthinyl-8-Thio] Acetic Acid Hydrazides
- Авторы: Valeeva L.A.1, Davlyatova G.G.1, Shabalina Y.V.1, Isakova A.V.1, Khaliullin F.A.1, Nikitina I.L.1
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Учреждения:
- Bashkir State Medical University
- Выпуск: Том 50, № 6 (2016)
- Страницы: 358-361
- Раздел: Search for New Drugs
- URL: https://ogarev-online.ru/0091-150X/article/view/244394
- DOI: https://doi.org/10.1007/s11094-016-1451-9
- ID: 244394
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Аннотация
2-[3-Methyl-7-(thietanyl-3)-1-ethylxanthinyl-8-thio]acetic acid hydrazide was synthesized in two steps by our improved method. The structures of the synthesized compounds were confirmed by IR and NMR spectroscopic data. The acute toxicity was studied. The LD50 values were 700 mg/kg for outbred albino mice. Tail-suspension tests (TST) and forced swimming tests (FST) found that 2-[3-methyl-7-(thietanyl-3)-1-ethylxanthinyl-8-thio]acetic acid hydrazide exhibited antidepressant activity that was most pronounced at a dose of 12 mg/kg.
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L. Valeeva
Bashkir State Medical University
Автор, ответственный за переписку.
Email: bsmu.pharmacology2@yandex.ru
Россия, 3 Lenina St., Ufa, Bashkortostan, 450000
G. Davlyatova
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Россия, 3 Lenina St., Ufa, Bashkortostan, 450000
Yu. Shabalina
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Россия, 3 Lenina St., Ufa, Bashkortostan, 450000
A. Isakova
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Россия, 3 Lenina St., Ufa, Bashkortostan, 450000
F. Khaliullin
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Россия, 3 Lenina St., Ufa, Bashkortostan, 450000
I. Nikitina
Bashkir State Medical University
Email: bsmu.pharmacology2@yandex.ru
Россия, 3 Lenina St., Ufa, Bashkortostan, 450000
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