Comparative Efficacies of Doxorubicin Complexes with Dextran Phosphate and Dextran Sulfate for Intracavity Chemotherapy of Zajdela Ascitic Hepatoma in Rats

Resumo

The efficacies of doxorubicin (Dox) complexes with carbohydrate polymers dextran phosphate (DP) and dextran sulfate (DS) in rats with grafted Zajdela ascitic hepatoma were studied in two series of experiments. The first studied the effects of the synthesized complexes on the cure rate and lifespan of the animals; the second, effects on ascites morphological parameters and Dox concentration in ascites fluid. The complexes were injected i.p. at a dose of 2 mg Dox/kg. The results showed that the Dox-DS complex reduced the lethality by 50% as compared with water-soluble Dox; the Dox-DP complex, by 28%. These complexes decreased statistically significantly the amount of ascites fluid and tumor-cell concentration in it. The drug was detected in ascites fluid 2 d after administration of Dox-DS and Dox-DP. The concentration of active ingredient in ascites fluid in animals treated with Dox-DS was >4 times higher than that in those treated with Dox-DP.