Synthesis and Anticonvulsant Activity of N-Substituted 4-Amino-3-Nitrocoumarins


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The synthesis and anticonvulsant activity of new coumarin derivatives are reported. N-(3-Nitrocoumarin-4-yl)-4-aminobutyric acid (1a) at doses of 60 and 80 mg/kg (in the MES test) and methyl N-(3,6-dinitrocoumarin-4-yl)-4-aminobutyrate (1e) at doses of 20 and 40 mg/kg (in the corazole antagonism test) possessed the greatest anticonvulsant activity of the synthesized compounds. The results indicated that the coumarin derivatives were promising for further development as potential anticonvulsant agents.

Sobre autores

G. Mokrov

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Autor responsável pela correspondência
Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315

V. Savel’ev

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315

T. Voronina

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315

S. Litvinova

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315

I. Kovalev

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315

L. Nerobkova

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315

A. Dmitrienko

A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

Email: g.mokrov@gmail.com
Rússia, 28 Vavilova St., Moscow, 119991

T. Gudasheva

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315

S. Seredenin

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315

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