Synthesis and Anticonvulsant Activity of N-Substituted 4-Amino-3-Nitrocoumarins
- Autores: Mokrov G.V.1, Savel’ev V.L.1, Voronina T.A.1, Litvinova S.A.1, Kovalev I.G.1, Nerobkova L.N.1, Dmitrienko A.O.2, Gudasheva T.A.1, Seredenin S.B.1
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Afiliações:
- V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- Edição: Volume 53, Nº 2 (2019)
- Páginas: 118-124
- Seção: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245630
- DOI: https://doi.org/10.1007/s11094-019-01964-7
- ID: 245630
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Resumo
The synthesis and anticonvulsant activity of new coumarin derivatives are reported. N-(3-Nitrocoumarin-4-yl)-4-aminobutyric acid (1a) at doses of 60 and 80 mg/kg (in the MES test) and methyl N-(3,6-dinitrocoumarin-4-yl)-4-aminobutyrate (1e) at doses of 20 and 40 mg/kg (in the corazole antagonism test) possessed the greatest anticonvulsant activity of the synthesized compounds. The results indicated that the coumarin derivatives were promising for further development as potential anticonvulsant agents.
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Sobre autores
G. Mokrov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Autor responsável pela correspondência
Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315
V. Savel’ev
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315
T. Voronina
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315
S. Litvinova
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315
I. Kovalev
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315
L. Nerobkova
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315
A. Dmitrienko
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: g.mokrov@gmail.com
Rússia, 28 Vavilova St., Moscow, 119991
T. Gudasheva
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315
S. Seredenin
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.com
Rússia, 8 Baltiiskaya St., Moscow, 125315
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