Synthesis and Anti-Ischemic Activity in Rats of Substituted N-Benzyl 1,2,5-Trimethyl-, 2,2,6,6-Tetramethylpiperidyl-, and Tropylamines

Resumo

Series of benzylidene and benzyl derivatives of 1,2,5-trimethyl-, 2,2,6,6-tetramethylpiperidyl-, and tropylamines were synthesized and screened for anti-ischemic activity in rats. The lead compound was identified as 2,2,6,6-tetramethyl-N-(3,4,5-trimethoxybenzyl)piperidin-4-amine, the anti-ischemic activity of which was statistically significantly greater than that of the reference drug trimetazidine in a myocardial subendocardial ischemia model.