Enviar artigo por via de e-mail Determination of Bacterial Endotoxins in Drugs: False-Negative Results
- Autores: Shapovalova O.V.1, Neugodova N.P.1, Sapozhnikova G.A.1, Simutenko L.V.1, Agashirinova A.A.1
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Afiliações:
- Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
- Edição: Volume 51, Nº 12 (2018)
- Páginas: 1119-1122
- Seção: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244937
- DOI: https://doi.org/10.1007/s11094-018-1751-3
- ID: 244937
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Resumo
One of the possible causes of false-negatives in bacterial endotoxin determinations, endotoxin aggregation and adsorption, was examined in a model experiment (positive control). A solution for eliminating the interfering actor using kinetic methods and a dispersing solvent was proposed based with the drug caspofungin as an example.
Sobre autores
O. Shapovalova
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd., Moscow, 127051
N. Neugodova
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd., Moscow, 127051
G. Sapozhnikova
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd., Moscow, 127051
L. Simutenko
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd., Moscow, 127051
A. Agashirinova
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
Email: chem@folium.ru
Rússia, 8/2 Petrovskii Blvd., Moscow, 127051
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