Synthesis and Anti-Arrhythmic Activity of the Chloride and Salicylate Salts of Morpholinoacetic Acid Ortho-Toluidide

Resumo

Acylation of ortho-toluidine hydrochloride by chloroacetylchloride followed by amination by morpholine in the presence of an excess of Et₃N produced morpholinoacetic acid ortho-toluidide and its salicylate salt. The acute toxicity and anti-arrhythmic and antifibrillatory activities of these compounds were studied. The biological activities indicated that these compounds were promising for further studies and evaluation of their potential for implementation into medical practice.