Enviar artigo por via de e-mail Synthesis and Antitumor Properties of New 1,2,4-Triazoles and 1,3,4-Thiadiazoles
- Autores: Ovsepyan T.R.1, Arsenyan F.G.1, Nersesyan L.E.1, Danielyan I.S.1, Agaronyan A.G.1, Melik-Ogandzhanyan R.G.1
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Afiliações:
- A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
- Edição: Volume 50, Nº 11 (2017)
- Páginas: 724-727
- Seção: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244467
- DOI: https://doi.org/10.1007/s11094-017-1520-8
- ID: 244467
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Resumo
New S-substituted derivatives were synthesized via alkylation of mercapto-substituted 1,2,4-triazoles and 1,3,4-thiadiazoles by various aliphatic and aromatic halides. Aminomethylation of 5-thio-1,2,4-triazoles formed the corresponding Mannich bases. The antitumor properties of the synthesized compounds against sarcoma 37 and EAC grafted tumor models and their influence on DNA methylation were studied
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Sobre autores
T. Ovsepyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armênia, 26 Azatutyan Pr., Yerevan, 0014
F. Arsenyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armênia, 26 Azatutyan Pr., Yerevan, 0014
L. Nersesyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armênia, 26 Azatutyan Pr., Yerevan, 0014
I. Danielyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armênia, 26 Azatutyan Pr., Yerevan, 0014
A. Agaronyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Email: melik@cornet.am
Armênia, 26 Azatutyan Pr., Yerevan, 0014
R. Melik-Ogandzhanyan
A. L. Mndzhoyan Institute of Fine Organic Chemistry, Science and Technology Center for Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia
Autor responsável pela correspondência
Email: melik@cornet.am
Armênia, 26 Azatutyan Pr., Yerevan, 0014
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