Synthesis and Antimicrobial Activity of 4-formylphenyl-N-phenylcarbamates

Resumo

Novel phenylcarbamates with isoxazole, nitrofuran, thiosemicarbazone, isonicotinoylhydrazide, and pyridine moieties were synthesized by [3+2]-cycloaddition and condensation reactions of 4-formylphenyl-N-phenylcarbamate. Their antimicrobial activities against museum strains of Gram-positive bacteria Staphylococcus aureus 209-P and Streptococcus pneumoniae, Gram-negative bacteria E. coli O18 and Pseudomonas aeruginosa 165, and human Micrococcus culture were studied. Derivatives with isoxazole, nitrofuran, and hydrazide moieties were the most active.