Comparative Dissolution Kinetics of Ibuprofen 200-Mg Capsules (Medisorb Co., Russia) and Ibuprofen 200-Mg Coated Tablets (Biosynthesis Co., Russia)

N. A. Prozorova; G. P. Vdovina; A. V. Bobrov

doi:10.1007/s11094-018-1800-y

Comparative Dissolution Kinetics of Ibuprofen 200-Mg Capsules (Medisorb Co., Russia) and Ibuprofen 200-Mg Coated Tablets (Biosynthesis Co., Russia)

作者: Prozorova N.A.¹^,2, Vdovina G.P.¹, Bobrov A.V.²
隶属关系:
1. E. A. Wagner Perm State Medical University
2. Medisorb Co.
期: 卷 52, 编号 3 (2018)
页面: 245-247
栏目: Structure of Chemical Compounds, Methods of Analysis and Process Control
URL: https://ogarev-online.ru/0091-150X/article/view/245103
DOI: https://doi.org/10.1007/s11094-018-1800-y
ID: 245103

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Experimental data on the comparative dissolution kinetics of two ibuprofen preparations from different manufacturers are presented. The study was performed in three buffer solutions at pH 1.2, 4.5, and 6.8 according to requirements of the Scientific Center for Expert Evaluation of Medicinal Products of the Russian Federation. A fourth dissolution medium was buffer solution at pH 7.2, which is included in a draft regulation. The test used a Erweka DT-720 rotating-basket device.