Synthesis and Pharmacological Properties of Linear Poly(Ethylene Glycol)s Conjugated to Interferon α-2b by Azo Coupling


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

A method for the preparation of pharmacologically active conjugates of interferon α-2b with poly(ethylene glycol)s that absorbed in the visible spectral range was proposed. New covalent conjugates of linear poly(ethylene glycol)s with interferon α-2b were prepared via diazotization of 4-aminobenzoic acid poly(ethylene glycol) esters followed by azo coupling of the obtained diazonium salts with histidine imidazoles and tyrosine phenols of the protein amino-acid chain. The synthesized conjugates retained a high degree of interferon α-2b antiviral activity in vitro and had longer blood circulation times than a foreign analog and very low acute toxicity and immunogenicity.

Авторлар туралы

S. Sheremet’ev

FORT LLC

Email: chem@folium.ru
Ресей, Ryazan, 390000

D. Lonshakov

FORT LLC

Email: chem@folium.ru
Ресей, Ryazan, 390000

S. Korovkin

FORT LLC

Email: chem@folium.ru
Ресей, Ryazan, 390000

E. Belosludtseva

FORT LLC

Email: chem@folium.ru
Ресей, Ryazan, 390000

A. Katlinskii

FORT LLC

Email: chem@folium.ru
Ресей, Ryazan, 390000

A. Semchenko

FORT LLC

Email: chem@folium.ru
Ресей, Ryazan, 390000

O. Borisova

I. I. Mechnikov Research Institute of Vaccines and Sera, Russian Academy of Medical Sciences

Email: chem@folium.ru
Ресей, Moscow, 105064

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

© Springer Science+Business Media New York, 2017