Email this article Syntheses of Melanotan II and YSL Amide by Ajiphase® Methodology
- Authors: Sanguliya T.A.1, Antipova A.O.1, Shkavrov S.V.1, Épshtein N.B.1
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Affiliations:
- National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
- Issue: Vol 53, No 5 (2019)
- Pages: 462-466
- Section: Drug Synthesis Methods and Manufacturing Technology
- URL: https://ogarev-online.ru/0091-150X/article/view/245812
- DOI: https://doi.org/10.1007/s11094-019-02020-0
- ID: 245812
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Abstract
The promising antitumor peptides Melanotan II and YSL amide were synthesized for the first time in gram quantities in overall yields of 72 and 50%, respectively, by Ajiphase® methodology. This method was shown to be promising for peptide manufacturing. The proposed methods are as convenient as polymer-phase syntheses with the reagent consumption and associated analytical simplicity of classical solution syntheses.
About the authors
T. A. Sanguliya
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: NBEpshtejn@mephi.ru
Russian Federation, Moscow, 115409
A. O. Antipova
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: NBEpshtejn@mephi.ru
Russian Federation, Moscow, 115409
S. V. Shkavrov
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Email: NBEpshtejn@mephi.ru
Russian Federation, Moscow, 115409
N. B. Épshtein
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Author for correspondence.
Email: NBEpshtejn@mephi.ru
Russian Federation, Moscow, 115409
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