Antiviral Properties of the New Coordination Compound Silver Bis(Citrato)Germanate

I. I. Seifullina; E. É. Martsinko; T. L. Gridina; E. A. Chebanenko; L. M. Mudrik; A. S. Fedchuk

doi:10.1007/s11094-019-01999-w

Antiviral Properties of the New Coordination Compound Silver Bis(Citrato)Germanate

Authors: Seifullina I.I.¹, Martsinko E.É.¹, Gridina T.L.², Chebanenko E.A.¹, Mudrik L.M.³, Fedchuk A.S.³
Affiliations:
1. I. I. Mechnikov Odessa National University
2. Odessa National Medical University
3. Odessa Research Center Biomedical Testing of Food and Drugs
Issue: Vol 53, No 4 (2019)
Pages: 318-321
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245750
DOI: https://doi.org/10.1007/s11094-019-01999-w
ID: 245750

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Abstract

The new coordination polymer silver bis(citrato)germanate was synthesized and exhibited pronounced antiviral activity against human influenza virus strains A/Hong Kong/1/68 (H3N2) and A/Puerto Rico/34 (H1N1). Its effective dose was five times lower than that of the reference drug oseltamivir, which made this compound promising for further studies in animal models.