Email this article Dissolution of Ketoprofen from Poly(Ethylene Glycol) Solid Dispersions
- Authors: Belyatskaya A.V.1, Krasnyuk I.I.1, Krasnyuk I.I.1, Stepanova O.I.1, Kosheleva T.M.1, Kudinova T.P.1, Vorob’ev A.N.2, Maryanyan M.M.1
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Affiliations:
- I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
- People’s Friendship University of Russia (RUDN University)
- Issue: Vol 52, No 12 (2019)
- Pages: 1001-1006
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245576
- DOI: https://doi.org/10.1007/s11094-019-01941-0
- ID: 245576
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Abstract
The effect of solid dispersions (SDs) on the solubility of the nonsteroidal anti-inflammatory drug ketoprofen was determined. Ketoprofen and its SDs with poly(ethylene glycol) PEG-400, -1000, -1500, -2000, and -3000 were studied. Dissolution of ketoprofen from the SDs increased by 1.2 – 1.8 times; the dissolution rate, by 1.7 – 2.4 times. The improved release of ketoprofen from the SDs was proposed to be due to several factors such as solubilization and amorphization of the compound and formation of intermolecular H-bonds. The results could be used to develop rapidly dissolving ketoprofen solid dosage forms.
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About the authors
A. V. Belyatskaya
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Author for correspondence.
Email: av.beliatskaya@mail.ru
Russian Federation, Moscow, 119991
I. I. Krasnyuk
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: av.beliatskaya@mail.ru
Russian Federation, Moscow, 119991
I. I. Krasnyuk
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: av.beliatskaya@mail.ru
Russian Federation, Moscow, 119991
O. I. Stepanova
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: av.beliatskaya@mail.ru
Russian Federation, Moscow, 119991
T. M. Kosheleva
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: av.beliatskaya@mail.ru
Russian Federation, Moscow, 119991
T. P. Kudinova
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: av.beliatskaya@mail.ru
Russian Federation, Moscow, 119991
A. N. Vorob’ev
People’s Friendship University of Russia (RUDN University)
Email: av.beliatskaya@mail.ru
Russian Federation, Moscow, 117198
M. M. Maryanyan
I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Email: av.beliatskaya@mail.ru
Russian Federation, Moscow, 119991
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