Antioxidant and Antiradical Activity of Drugs Intended for Treating Ophthalmic Disorders

A. V. Ivanova; E. L. Gerasimova; E. R. Gazizullina; Ya. A. Okulova; A. I. Matern; V. L. Rusinov

doi:10.1007/s11094-018-1883-5

Antioxidant and Antiradical Activity of Drugs Intended for Treating Ophthalmic Disorders

Authors: Ivanova A.V.¹, Gerasimova E.L.¹, Gazizullina E.R.¹, Okulova Y.A.¹, Matern A.I.¹, Rusinov V.L.¹
Affiliations:
1. Institute of Chemical Technology, B. N. Yeltsin Ural Federal University
Issue: Vol 52, No 8 (2018)
Pages: 694-699
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245415
DOI: https://doi.org/10.1007/s11094-018-1883-5
ID: 245415

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Abstract

Dosage forms intended for ophthalmic use with declared and potential antioxidant properties were investigated. Antioxidant activity was determined using potentiometry with potassium hexacyanoferrate (III) as the oxidant. Antiradical activity was studied using the stable radical 2,2-diphenyl-1-picrylhydrazyl. The reaction half-lives of the investigated dosage forms were determined. Ratios of the experimental antioxidant activity to the content of main active ingredient were assessed.