Email this article Effects of Novel Potential Analgesic Compounds on the Cardiovascular and Respiratory Systems
- Authors: Palikova Y.A.1,2, Skobtsova L.A.1,2, Palikov V.A.1,2, Belous G.I.2, Khokhlova O.N.1,3, Lobanov A.V.1,3, Slashcheva G.A.1, Rzhevskii D.I.1,3, Rudenko V.B.1, Kalabina E.A.1, Osipova G.A.1, Andreev Y.A.4,5, Logashina Y.A.4,5, Kozlov S.A.4, Yavorskii A.N.2, Elyakova G.4, D’yachenko I.A.1,3,2
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Affiliations:
- Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Pushchino State Natural Sciences Institute
- Pushchino Scientific Center, Russian Academy of Sciences
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- First I. M. Sechenov Moscow State Medical University, Russian Ministry of Health, Institute of Molecular Medicine
- Issue: Vol 52, No 7 (2018)
- Pages: 593-595
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245360
- DOI: https://doi.org/10.1007/s11094-018-1865-7
- ID: 245360
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Abstract
The polypeptide analgesic compounds APCH3 (a TRPV1 receptor inhibitor) and PT1 (a P2X3 receptor inhibitor) were shown not to act on the cardiovascular system or respiratory system when given either as single or multiple doses in mice. The low molecular weight compound sevanol (an ASIC3 receptor inhibitor) had no effect on the cardiovascular system, but prolonged use for 14 days affected measures of the respiratory system, significantly increasing respiratory rate and peak expiratory flow rate.
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About the authors
Yu. A. Palikova
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pushchino State Natural Sciences Institute
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290; 3, Prospekt Nauki, Pushchino, Moscow Region, 142290
L. A. Skobtsova
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pushchino State Natural Sciences Institute
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290; 3, Prospekt Nauki, Pushchino, Moscow Region, 142290
V. A. Palikov
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pushchino State Natural Sciences Institute
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290; 3, Prospekt Nauki, Pushchino, Moscow Region, 142290
G. I. Belous
Pushchino State Natural Sciences Institute
Email: chem@folium.ru
Russian Federation, 3, Prospekt Nauki, Pushchino, Moscow Region, 142290
O. N. Khokhlova
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290; 3, Prospekt Nauki, Pushchino, Moscow Region, 142290
A. V. Lobanov
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290; 3, Prospekt Nauki, Pushchino, Moscow Region, 142290
G. A. Slashcheva
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290
D. I. Rzhevskii
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290; 3, Prospekt Nauki, Pushchino, Moscow Region, 142290
V. B. Rudenko
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290
E. A. Kalabina
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290
G. A. Osipova
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290
Ya. A. Andreev
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; First I. M. Sechenov Moscow State Medical University, Russian Ministry of Health, Institute of Molecular Medicine
Email: chem@folium.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997; 8 Trubetskaya Street, Moscow, 119991
Yu. A. Logashina
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; First I. M. Sechenov Moscow State Medical University, Russian Ministry of Health, Institute of Molecular Medicine
Email: chem@folium.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997; 8 Trubetskaya Street, Moscow, 119991
S. A. Kozlov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
A. N. Yavorskii
Pushchino State Natural Sciences Institute
Email: chem@folium.ru
Russian Federation, 3, Prospekt Nauki, Pushchino, Moscow Region, 142290
G. Elyakova
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: chem@folium.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
I. A. D’yachenko
Branch of M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Pushchino Scientific Center, Russian Academy of Sciences; Pushchino State Natural Sciences Institute
Email: chem@folium.ru
Russian Federation, 6, Prospekt Nauki, Pushchino, Moscow Region, 142290; 3, Prospekt Nauki, Pushchino, Moscow Region, 142290; 3, Prospekt Nauki, Pushchino, Moscow Region, 142290
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