Preparation of Gallic Acid – Anhydride Conjugate and Evaluation of Prodrug Release Through Pva-Based Hydrogel

Abstract

In continuation of our previous work, we have studied controlled release of gallic acid – anhydride (GAAN) conjugate prodrug through crosslinked-PVAbased hydrogel. The GAAN conjugate prodrug was prepared and incorporated into PVA-based hydrogel in order to formulate a drug delivery system with controlled release properties. The loaded and unloaded hydrogels were investigated by FTIR spectroscopy. Their thermal stability was studied by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The drug release was studied spectrophotometrically, and the obtained data were interpreted in the framework of zero-order, first-order, Higuchi and Korsmeyer – Peppas models.