Email this article Synthesis and Antiradical and Hemorheological Activity of Compounds Based on 2,6-Diisobornyl-4-Methylphenol and Polysaccharides
- Authors: Plotnikov M.B.1, Aliev O.I.1, Sidekhmenova A.V.1, Popova E.V.1, Ostrikova O.I.1, Kuchin A.V.2, Chukicheva I.Y.2, Torlopov M.A.2
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
- Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences
- Issue: Vol 51, No 10 (2018)
- Pages: 863-866
- Section: Search for New Drugs
- URL: https://ogarev-online.ru/0091-150X/article/view/244832
- DOI: https://doi.org/10.1007/s11094-018-1705-9
- ID: 244832
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Abstract
Antiradical and hemorheological activities of conjugates synthesized from 2,6-diisobornyl-4-methylphenol (dibornol) and polysaccharides [inulin, carboxymethylcellulose, hydroxyethyl starch (HES)] were studied in vitro. The dibornol—HES polymer conjugate exhibited the greatest antiradical activity of the tested compounds for the water-soluble stable radical ABTS•+ and limited statistically significantly the blood viscosity increase in an in vitro blood hyperviscosity model at a final concentration of 10–5 g/ml of blood.
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About the authors
M. B. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Author for correspondence.
Email: mbp2001@mail.ru
Russian Federation, 3 Prosp. Lenina, Tomsk, 634028
O. I. Aliev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Email: mbp2001@mail.ru
Russian Federation, 3 Prosp. Lenina, Tomsk, 634028
A. V. Sidekhmenova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Email: mbp2001@mail.ru
Russian Federation, 3 Prosp. Lenina, Tomsk, 634028
E. V. Popova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Email: mbp2001@mail.ru
Russian Federation, 3 Prosp. Lenina, Tomsk, 634028
O. I. Ostrikova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Email: mbp2001@mail.ru
Russian Federation, 3 Prosp. Lenina, Tomsk, 634028
A. V. Kuchin
Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, 48 Pervomaiskaya St., Syktyvkar, Komi Republic, 167982
I. Yu. Chukicheva
Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, 48 Pervomaiskaya St., Syktyvkar, Komi Republic, 167982
M. A. Torlopov
Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences
Email: mbp2001@mail.ru
Russian Federation, 48 Pervomaiskaya St., Syktyvkar, Komi Republic, 167982
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