Email this article Separation of Camptothecin by Ethanol/K2CO3 Aqueous Two-Phase System Containing Tetramethylguanidine
- Authors: Zhu J.1, Jin Z.1
-
Affiliations:
- College of Pharmaceutical Sciences, Zhejiang University of Technology
- Issue: Vol 51, No 6 (2017)
- Pages: 491-493
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244669
- DOI: https://doi.org/10.1007/s11094-017-1640-1
- ID: 244669
Cite item
Open Access
Access granted
Subscription Access
Abstract
Insoluble camptothecin was converted into the corresponding hydrosoluble analog, camptothecin carboxylate, by using 1,1,3,3-tetramethylguanidine as hydrolyzing agent. The ethanol/K2CO3/H2O aqueous two-phase system was established to extract the hydrosoluble camptothecin carboxylate. Through two-stage extraction from crude camptothecin of 5.4%, purity, final hydrosoluble camptothecin was obtained with a purity of 98.5% at a total yield of 78.4%.
About the authors
Jian Zhu
College of Pharmaceutical Sciences, Zhejiang University of Technology
Email: zdjin99@sina.com
China, Hangzhou, 310014
Zhi-Min Jin
College of Pharmaceutical Sciences, Zhejiang University of Technology
Author for correspondence.
Email: zdjin99@sina.com
China, Hangzhou, 310014
Supplementary files
