Synthesis and Pharmacological Potential of New 3-Mercapto-4-Amino(Pyrrolyl-1)-5-(Thienyl-2)-1,2,4-Triazole(4 H ) Derivatives

N. B. Saidov; V. A. Georgiyants; E. Yu. Lipakova

doi:10.1007/s11094-017-1551-1

Synthesis and Pharmacological Potential of New 3-Mercapto-4-Amino(Pyrrolyl-1)-5-(Thienyl-2)-1,2,4-Triazole(4H) Derivatives

Authors: Saidov N.B.¹, Georgiyants V.A.², Lipakova E.Y.³
Affiliations:
1. Tadzhik National University
2. National Pharmaceutical University
3. Kharkov Postgraduate Medical Academy
Issue: Vol 51, No 1 (2017)
Pages: 26-29
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244498
DOI: https://doi.org/10.1007/s11094-017-1551-1
ID: 244498

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Abstract

A synthesis of 4-amino-5-(2-thienyl)-1,2,4-triazol(4H)-3-ylthioacetanilides was developed, and these were chemically modified to produce 2-[5-(2′-thienyl-4-(1H-1-pyrrolyl)-4H-1,2,4-triazol-3-ylthio]acetanilidfes. The structures of the synthetic compounds were confirmed by 1H NMR spectroscopy. Predictions of pharmacological activity showed that the compounds synthesized here were likely to act on the CNS. The antitumor activity of the study compounds was assessed.