Synthesis and Anticonvulsant Activity of 7(8)-Amino Derivatives of Condensed Thieno[3,2- d ]Pyrimidines

S. N. Sirakanyan; E. K. Akopyan; R. G. Paronikyan; A. G. Akopyan; A. A. Ovakimyan

doi:10.1007/s11094-016-1439-5

Synthesis and Anticonvulsant Activity of 7(8)-Amino Derivatives of Condensed Thieno[3,2-d]Pyrimidines

Authors: Sirakanyan S.N.¹, Akopyan E.K.¹, Paronikyan R.G.¹, Akopyan A.G.¹, Ovakimyan A.A.¹
Affiliations:
1. A. L. Mnjoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Issue: Vol 50, No 5 (2016)
Pages: 296-300
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244366
DOI: https://doi.org/10.1007/s11094-016-1439-5
ID: 244366

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Abstract

Methods for synthesizing novel amino derivatives of cyclopenta[4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines and tetrahydropyrimido[4′,5′:4,5]thieno[2,3-c]isoquinoline from 3-chloro derivatives of alicyclo[c]pyridines were elaborated. Studies of the anticonvulsant activity of the synthesized compounds showed that they exhibited pronounced anticonvulsant activity and low toxicity.