Convenient Four-Step Synthesis of H-Pyr-His-Trp-OH, a Key Tripeptide Intermediate for the Production of Synthetic Gonadoliberin Agonists

A. N. Balaev; K. A. Okhmanovich; V. E. Fedorov

doi:10.1007/s11094-016-1421-2

Convenient Four-Step Synthesis of H-Pyr-His-Trp-OH, a Key Tripeptide Intermediate for the Production of Synthetic Gonadoliberin Agonists

Authors: Balaev A.N.¹, Okhmanovich K.A.¹, Fedorov V.E.¹
Affiliations:
1. Pharm-Sintez Co., 8 2nd Roshchinskii Proezd
Issue: Vol 50, No 3 (2016)
Pages: 192-194
Section: Article
URL: https://ogarev-online.ru/0091-150X/article/view/244342
DOI: https://doi.org/10.1007/s11094-016-1421-2
ID: 244342

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Abstract

An effective four-step synthesis of the tripeptide H-Pyr-His-Trp-OH that is used to produce synthetic gonadoliberin agonists was developed. The synthesis was carried out without adding and removing protecting groups and could produce the target compound with >98% purity.