Synthesis and Estimation of the Influence of 2,4-Dimethoxyphenylbiguanide on the Glutathione Antioxidant System Activity in Heart and Blood Serum of Rats with Experimental Rheumatoid Arthritis

Resumo

A synthetic method for 2,4-dimethoxyphenylbiguanide, which was selected using the Prediction of Activity Spectra of Substances (PASS) computer program, was developed. The influence of this novel biguanidine derivative on the content of reduced glutathione and the activities of glutathione peroxidase, glutathione reductase, and glutathione transferase in the heart and blood serum of rats with experimental rheumatoid arthritis was estimated. The studied parameters changed toward the control values after the test compound was injected into animals with the pathology, which could be explained by manifestation of its cardioprotective and antioxidant activities. The obtained data could be used to develop new methods for prevention and treatment of this pathological condition.