The impact of intradermal injections of modified hyaluronic acid on the morphological skin condition in female patients with involutional changes
- 作者: MIKHAILOVA NP1
-
隶属关系:
- I.M. Sechenov First Moscow State Medical University
- 期: 卷 89, 编号 5 (2013)
- 页面: 152-159
- 栏目: Articles
- URL: https://ogarev-online.ru/0042-4609/article/view/117139
- DOI: https://doi.org/10.25208/vdv608
- ID: 117139
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详细
Goal. To provide a clinical assessment of the efficacy and tolerance of hyaluronic acid (HA) drugs modified with vitamin С and amino acids in patients with involutional skin changes. Methods. As many as 90 female patients underwent a course of treatment for age-related skin changes including three procedures of intradermal injections of modified HA. The skin condition was assessed prior to and after the treatment by using non-invasive methods (corneometry, pH-metry, sebometry, elastometry, visio-scanning, ultrasonic derma-scanning and confocal laser scanning microscopy). Results. The authors demonstrated good tolerance of modified HA and skin condition improvement (better elasticity, moisture level, improvement of the skin structure and microrelief, reduction in the intensity of expression and static wrinkles, restoration of color uniformity and elimination of xerosis manifestations). Conclusion. The study results are sufficient to recommend modified HA drugs for correcting involutional skin changes.
作者简介
N MIKHAILOVA
I.M. Sechenov First Moscow State Medical University
Email: mikhailova@martinex.ru
врач-дерматовенеролог, аспирант кафедры кожных и венерических болезней
参考
- Марголина А.А., Эрнандес Е.И., Зайкина О.Э. Новая косметология. М: Косметика и Медицина 2002; 2: 6-15
- Antoniou C., Kosmadaki M.G., Stratigos A.J., Katsambas A.D. Photoaging: prevention and topical treatments. Am J Clin Dermatol 2010; 11 (2): 95-102
- Жирнова Н.С., Любовцева Л.А., Гурьянова Е.А. Люминесцентно-гистохимическое изучение гистамина в структурах кожи после введения препаратов гиалуроновой кислоты. Рос журн кожн и венерич болезней 2007; 6: 57-59
- Хадарцева К.А., Хадарцев А.А., Рязанова Е.А., Руднева Н.С. Новые способы диагностики и восстановительного лечения. Фундаментальные исследования 2007; 117
- Bollyky P.L., Falk B.A., Wu R.P. et al. Intact extracellularmatrix and the maintenance of immunetolerance: high molecular weight hyaluronan promotespersistence of induced CD4+CD25+ regulatoryT cells. J Leukoc Biol 2009; 86: 567-572
- Day A.J., de la Motte C.A. Hyaluronan crosslinking: a protective mechanism in inflammation? Trends Immunol 2005; 26: 637-643
- Della Valle F., Romeo A. Hyaluronic acid fraction-shaving pharmaceutical activity, and pharmaceutical compositions containing the same. Patent US. - №5925626. - 1999
- Хабаров В.Н., Бойков П.Я., Селянин М.А. Гиалуроновая кислота. М.: Практическая медицина 2012; 224
- Хабаров В.Н., Зеленецкий А.Н. Нанотехнологическая ретикуляция гиалуроновой кислоты. КИ2008; 2: 8-14
- Гланц С. Медико-биологическая статистика. М: Практика 1999; 460
- Дубинская В.А., Виноградова Е.В. Кожа человека: влагообмен и старение. Клин геронтол 2000; 7-8; 22-26
- Chung J.H., Hanft V.N., Kang S. Aging and photoaging. J Am Acad Dermatol 2003; 49 (4): 690-697
- Millis A. Differetial expression of metalloproteinaseand tissue inhibitor of metalloproteinase genes in aged human fibroblaste. Exp Cell Res1992; 201: 373-378
- Shibayama H., Hisama M., Matsuda S. et al. Effect of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate on human dermal fibroblasts: increased collagen synthesis and inhibition of MMP-1. Biol Pharm Bull 2008; 31 (4): 563-568
- Овчинников Ю.А. Биоорганическая химия. М.: Просвещение 1987; 815
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