A Complex Study of the Peculiarities of Blood Serum Absorption of Rats with Experimental Liver Cancer

Resumo

Terahertz time-domain spectroscopy (THz-TDS) in the 0.05–1.0 THz frequency range was used to study the blood serum of rats in the dynamics of experimental liver cancer. It was shown that the THz transmission spectra of samples from healthy animals and 14 and 28 days after tumor cells implantation are similar in shape, but differ in amplitude. There is a change in the biochemical composition of the blood, including a decrease in the protein content, by the 28th day of the experiment. The observed changes in the THz response are explained by a decrease in the number of protein molecules and bound water and correlate with changes in the refractive index in the visible and near-IR ranges from 480 to 1550 nm, measured using a multiwave refractometer.