Enviar artigo por via de e-mail Advanced Nanotools for Imaging of Solid Tumors and Circulating and Disseminated Cancer Cells
- Autores: Ramos-Gomes F.1, Alves F.1,2, Chames P.3, Baty D.3, Nabiev I.4,5, Sukhanova A.4,5
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Afiliações:
- Translational Molecular Imaging Unit, Max Planck Institute for Experimental Medicine
- Clinic of Haematology and Medical Oncology, University Medical Center Göttingen
- Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche Contre le Cancer de Marseille (CRCM)
- Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
- Laboratoire de Recherche en Nanosciences, LRN-EA4682, Ulniversité de Reims Champagne-Ardenne
- Edição: Volume 125, Nº 5 (2018)
- Páginas: 703-707
- Seção: Nanophotonics
- URL: https://ogarev-online.ru/0030-400X/article/view/165846
- DOI: https://doi.org/10.1134/S0030400X18110309
- ID: 165846
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Resumo
Semiconductor quantum dots (QDs) are characterized by orders of magnitude higher multiphoton linear absorption cross-sections compared with conventional organic dyes. Combined with the QD photoluminescence quantum yield approaching 100% and their rock-solid photostability, this fact opens great prospects for the two-photon functional tumor imaging with QDs tagged with highly specific recognition molecules. Single-domain antibodies (sdAbs) or “nanobodies” derived from lamas are the smallest high-affinity recognition molecules, which may be tagged with the QDs thus permitting not only solid tumors multiphoton imaging but also rare disseminated cancer cells and micrometastases in the depth of the tissue to be detected.
Sobre autores
F. Ramos-Gomes
Translational Molecular Imaging Unit, Max Planck Institute for Experimental Medicine
Email: igor.nabiev@univ-reims.fr
Alemanha, Göttingen, 37075
F. Alves
Translational Molecular Imaging Unit, Max Planck Institute for Experimental Medicine; Clinic of Haematology and Medical Oncology, University Medical Center Göttingen
Email: igor.nabiev@univ-reims.fr
Alemanha, Göttingen, 37075; Göttingen, 37075
P. Chames
Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes,Centre de Recherche Contre le Cancer de Marseille (CRCM)
Email: igor.nabiev@univ-reims.fr
França, Marseille, 13009
D. Baty
Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes,Centre de Recherche Contre le Cancer de Marseille (CRCM)
Email: igor.nabiev@univ-reims.fr
França, Marseille, 13009
I. Nabiev
Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI(Moscow Engineering Physics Institute); Laboratoire de Recherche en Nanosciences, LRN-EA4682, Ulniversité de Reims Champagne-Ardenne
Autor responsável pela correspondência
Email: igor.nabiev@univ-reims.fr
Rússia, Moscow, 115409; Reims, 51100
A. Sukhanova
Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI(Moscow Engineering Physics Institute); Laboratoire de Recherche en Nanosciences, LRN-EA4682, Ulniversité de Reims Champagne-Ardenne
Email: igor.nabiev@univ-reims.fr
Rússia, Moscow, 115409; Reims, 51100
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