Отправить статью по E-mail Hormonal regulation of NK cell cytotoxic activity
- Авторы: Shirshev S.V.1, Nekrasova I.V.1, Gorbunova O.L.1, Orlova E.G.1
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Учреждения:
- Institute of Ecology and Genetics of Microorganisms, Ural Division
- Выпуск: Том 472, № 1 (2017)
- Страницы: 28-30
- Раздел: Cell Biology
- URL: https://ogarev-online.ru/0012-4966/article/view/153978
- DOI: https://doi.org/10.1134/S0012496617010021
- ID: 153978
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Аннотация
The effects of chorionic gonadotropin, estriol (E3), leptin, ghrelin, and kisspeptin on the intracellular expression of perforin, granzyme A, and granzyme B was studied in separated NK cells. All studied hormones except E3 are could modulate the expression of cytotoxic enzymes in NK cells by suppression of the expression of the most active proapoptotic agents, resulting in increased expression of granzyme A, which is typical of the decidual subpopulation of these lymphocytes.
Об авторах
S. Shirshev
Institute of Ecology and Genetics of Microorganisms, Ural Division
Автор, ответственный за переписку.
Email: shirshev@iegm.ru
Россия, Perm, 614081
I. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: shirshev@iegm.ru
Россия, Perm, 614081
O. Gorbunova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: shirshev@iegm.ru
Россия, Perm, 614081
E. Orlova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: shirshev@iegm.ru
Россия, Perm, 614081
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