Отправить статью по E-mail Effect of pregnancy-specific β1-glycoprotein on indoleamine-2,3-dioxygenase activity in human monocytes
- Авторы: Zamorina S.A.1,2, Timganova V.P.1, Bochkova M.S.1, Khramtsov P.V.2, Raev M.B.1,3
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Учреждения:
- Institute of Ecology and Genetics of Microorganisms, Ural Division
- Perm State National Research University
- Yeltsin Ural Federal University
- Выпуск: Том 469, № 1 (2016)
- Страницы: 206-208
- Раздел: Cell Biology
- URL: https://ogarev-online.ru/0012-4966/article/view/153825
- DOI: https://doi.org/10.1134/S0012496616040165
- ID: 153825
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Аннотация
The role of heterogenic human pregnancy-specific glycoprotein (PSG), obtained by the authors’ technology, in the regulation of the indoleamine-2,3-dioxygenase (IDO) activity in female blood monocytes has been studied in vitro. PSG stimulated IDO activity under the conditions of induction of the monocytes by interferon-γ. Upon the induction of cell proliferation by lipopolysaccharides, the stimulating effect was obtained only with 10 μg/mL of PSG. Enhanced IDO activity is probably a factor of peripheral immunological tolerance and antimicrobial protection against intracellular infections in the gestation period.
Об авторах
S. Zamorina
Institute of Ecology and Genetics of Microorganisms, Ural Division; Perm State National Research University
Автор, ответственный за переписку.
Email: mantissa7@mail.ru
Россия, Perm; Perm
V. Timganova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: mantissa7@mail.ru
Россия, Perm
M. Bochkova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: mantissa7@mail.ru
Россия, Perm
P. Khramtsov
Perm State National Research University
Email: mantissa7@mail.ru
Россия, Perm
M. Raev
Institute of Ecology and Genetics of Microorganisms, Ural Division; Yeltsin Ural Federal University
Email: mantissa7@mail.ru
Россия, Perm; Yekaterinburg
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