Enviar artigo por via de e-mail α-Fetoprotein Influence on the Conversion of Naïve T-Helpers into Memory T-Cell Effector Subpopulations
- Autores: Zamorina S.A.1,2, Timganova V.P.1, Bochkova M.S.1, Khramtsov P.V.1,2, Fomicheva K.A.2, Rayev M.B.1,2,3, Chereshnev V.A.1,2,3
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Afiliações:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch
- Perm State National Research University
- Ural Federal University
- Edição: Volume 482, Nº 1 (2018)
- Páginas: 210-213
- Seção: Cell Biology
- URL: https://ogarev-online.ru/0012-4966/article/view/154389
- DOI: https://doi.org/10.1134/S0012496618050113
- ID: 154389
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Resumo
The effect of native α-fetoprotein (AFP) on the conversion of naïve T-helpers into central memory T-cells (TCM) and effector subpopulations of the preterminally differentiated (TEM) and terminally differentiated (TEMRA) memory T-cells was studied. AFP was found to prevent the conversion of naïve T-helpers into effector subpopulations of memory T cells (TEM and TEMRA) while reducing the total production of IL-4 and IFN-γ by the studied cell populations. The data reveal a new role of AFP in the immune tolerance formation during pregnancy.
Sobre autores
S. Zamorina
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University
Email: timganovavp@gmail.com
Rússia, Perm; Perm
V. Timganova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Autor responsável pela correspondência
Email: timganovavp@gmail.com
Rússia, Perm
M. Bochkova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: timganovavp@gmail.com
Rússia, Perm
P. Khramtsov
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University
Email: timganovavp@gmail.com
Rússia, Perm; Perm
K. Fomicheva
Perm State National Research University
Email: timganovavp@gmail.com
Rússia, Perm
M. Rayev
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University; Ural Federal University
Email: timganovavp@gmail.com
Rússia, Perm; Perm; Yekaterinburg
V. Chereshnev
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University; Ural Federal University
Email: timganovavp@gmail.com
Rússia, Perm; Perm; Yekaterinburg
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