Remote effects of short-term neonatal hyperthermia in Krushinsky–Molodkina rats prone to audiogenic seizures strain

Abstract

Using the audiogenic seizure prone Krushinsky–Molodkina rat strain, it was demonstrated that short-term (5 min) exposure of 14-day-old pups to an elevated temperature (42°C) resulted in a significant decrease in audiogenic seizure severity at the age of 1 month. Presumably, this effect is determined by the activation of the heat-shock protein system (stress proteins).