Age-Dependent Changes in Na+,K+-ATPase Activity and Lipid Peroxidation in Membranes of Erythrocytes during Cardiosclerosis Development in Rats


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Activity of Na+,K+-ATPase was measured in erythrocyte ghosts of 4- and 12-month-old rats, intact and with postinfarction cardiosclerosis. Enhanced accumulation of secondary LPO products and reduced activity of Na+,K+-ATPase were observed in erythrocyte ghosts of 12-month-old rats. The development of postinfarction cardiosclerosis in 4-month-old rats was accompanied by enhanced accumulation of LPO products and decreased activity of Na+,K+-ATPase. In comparison with young rats with postinfarction cardiosclerosis, 12-month-old rats with this pathology were characterized by less pronounced decrease in Na+,K+-ATPase activity and increase in accumulation of LPO products in comparison with intact control.

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T. Rebrova

Research Institute of Cardiology

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Email: rebrova@cardio-tomsk.ru
俄罗斯联邦, Tomsk

S. Afanasiev

Research Institute of Cardiology

Email: rebrova@cardio-tomsk.ru
俄罗斯联邦, Tomsk

S. Popov

Research Institute of Cardiology

Email: rebrova@cardio-tomsk.ru
俄罗斯联邦, Tomsk

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