Expression of Beclin-1 and LAMP-2 in Rat Hippocampus under Conditions of Simulated Gravity Overload in the Caudocranial Vector
- Авторы: Smirnov A.1,2, Mednikov D.S.1, Shmidt M.V.1,2, Kurkin D.V.3, Bakulin D.A.3, Volotova E.V.3, Tyurenkov I.N.3
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Учреждения:
- Department of Pathological Anatomy
- Volgograd Medical Research Center
- Department of Pharmacology and Biopharmaceutics, Doctor Improvement Faculty, Volgograd State Medical University
- Выпуск: Том 165, № 1 (2018)
- Страницы: 105-109
- Раздел: Morphology and Pathomorphology
- URL: https://ogarev-online.ru/0007-4888/article/view/240030
- DOI: https://doi.org/10.1007/s10517-018-4109-7
- ID: 240030
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Аннотация
Structural changes in the rat hippocampus in response to chronic cerebrovascular disorders induced by gravity exposure in the caudocranial vector were studied. Qualitative and quantitative morphological analysis detected significant cytoarchitectonic changes in the pyramidal layer: spongiosis, manifest pericellular and perivascular edema, and a drastic increase in the counts of pyramidal neurons with signs of impairment in all hippocampal zones. The density of perikarya in the pyramidal layer decreased. Immunohistochemical study detected high expression of Beclin-1 in CA1 field. High expression of LAMP-2 was detected in CA4 field. Field CA2 was characterized by the maximum counts of damaged cells and high expression of Beclin-1 and LAMP-2.
Об авторах
A.V. Smirnov
Department of Pathological Anatomy; Volgograd Medical Research Center
Email: mednikov1988@gmail.com
Россия, Volgograd; Volgograd
D. Mednikov
Department of Pathological Anatomy
Автор, ответственный за переписку.
Email: mednikov1988@gmail.com
Россия, Volgograd
M. Shmidt
Department of Pathological Anatomy; Volgograd Medical Research Center
Email: mednikov1988@gmail.com
Россия, Volgograd; Volgograd
D. Kurkin
Department of Pharmacology and Biopharmaceutics, Doctor Improvement Faculty, Volgograd State Medical University
Email: mednikov1988@gmail.com
Россия, Volgograd
D. Bakulin
Department of Pharmacology and Biopharmaceutics, Doctor Improvement Faculty, Volgograd State Medical University
Email: mednikov1988@gmail.com
Россия, Volgograd
E. Volotova
Department of Pharmacology and Biopharmaceutics, Doctor Improvement Faculty, Volgograd State Medical University
Email: mednikov1988@gmail.com
Россия, Volgograd
I. Tyurenkov
Department of Pharmacology and Biopharmaceutics, Doctor Improvement Faculty, Volgograd State Medical University
Email: mednikov1988@gmail.com
Россия, Volgograd
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