Отправить статью по E-mail Myocardial Protection against Ischemic and Reperfusion Injuries (Experimental Study)
- Авторы: Mandel’ I.A.1, Podoksenov A.Y.2, Sukhodolo I.V.3, Podoksenov Y.K.2,3, Svirko Y.S.2,3, Kamenshchikov N.O.2, Mikheev S.L.2,3, Sementsov A.S.2, Rogovskaya Y.V.2, An D.A.3, Shipulin V.M.2,3, Maslov L.N.2
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Учреждения:
- Federal Research Clinical Center, Federal Medical-Biological Agency
- Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Выпуск: Том 164, № 1 (2017)
- Страницы: 21-25
- Раздел: Article
- URL: https://ogarev-online.ru/0007-4888/article/view/239329
- DOI: https://doi.org/10.1007/s10517-017-3917-5
- ID: 239329
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Аннотация
The effects of hypoxic, hyperoxic, and hypoxic-hyperoxic preconditioning were examined in the prospective study on narcotized and artificially ventilated rabbits. Under artificial circulation, acute myocardial ischemia was modeled by ligation of anterior descending coronary artery, which was followed by reperfusion. The degree of ventricular arrhythmias was assessed, and the ischemic area was evaluated in percent of the area at risk. Microscopic characterization of the myocardium was employed to assess the cardioprotective effect of hypoxic and/or hyperoxic preconditioning. According to Kruskal—Wallis test, the greatest resistance of the myocardium to ischemic and reperfusion injury was observed after hypoxic-hyperoxic preconditioning (H=42.459; p=0.009). The rabbits subjected to this type of preconditioning demonstrated the least damaged myocardium in comparison with nonconditioned controls.
Об авторах
I. Mandel’
Federal Research Clinical Center, Federal Medical-Biological Agency
Автор, ответственный за переписку.
Email: irina.a.mandel@gmail.com
Россия, Moscow
A. Podoksenov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Россия, Tomsk
I. Sukhodolo
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Россия, Tomsk
Yu. Podoksenov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Россия, Tomsk; Tomsk
Yu. Svirko
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Россия, Tomsk; Tomsk
N. Kamenshchikov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Россия, Tomsk
S. Mikheev
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Россия, Tomsk; Tomsk
A. Sementsov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Россия, Tomsk
Yu. Rogovskaya
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Россия, Tomsk
D. An
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Россия, Tomsk
V. Shipulin
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University, Ministry of Health of the Russian Federation
Email: irina.a.mandel@gmail.com
Россия, Tomsk; Tomsk
L. Maslov
Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: irina.a.mandel@gmail.com
Россия, Tomsk
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