Development of Endoplasmic Reticulum Stress during Experimental Oxalate Nephrolithiasis


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Morphological and ultrastructural study of the kidney was performed in rats with oxalate nephrolithiasis. Specific features of endoplasmic reticulum stress were evaluated during nephrolithiasis and treatment with α-tocopherol. We observed the signs of endoplasmic reticulum stress with activation of proapoptotic pathways and injury to the cell lining in nephron tubules and collecting ducts. Ultrastructural changes were found in the organelles, nuclei, and cell membranes of epitheliocytes. A relationship was revealed between endoplasmic reticulum stress and oxidative damage, which developed at the early state of lithogenesis.

Sobre autores

Yu. Motin

Altai State Medical University

Autor responsável pela correspondência
Email: pathol@inbox.ru
Rússia, Barnaul

A. Lepilov

Altai State Medical University

Email: pathol@inbox.ru
Rússia, Barnaul

N. Bgatova

Research Institute of Clinical and Experimental Lymphology

Email: pathol@inbox.ru
Rússia, Novosibirsk

A. Zharikov

Altai State Medical University

Email: pathol@inbox.ru
Rússia, Barnaul

N. Motina

Altai State Medical University

Email: pathol@inbox.ru
Rússia, Barnaul

G. Lapii

Institute of Molecular Pathology and Pathomorphology

Email: pathol@inbox.ru
Rússia, Novosibirsk

E. Lushnikova

Institute of Molecular Pathology and Pathomorphology

Email: pathol@inbox.ru
Rússia, Novosibirsk

L. Nepomnyashchikh

Institute of Molecular Pathology and Pathomorphology

Email: pathol@inbox.ru
Rússia, Novosibirsk

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