A Study of the Antioxidative and Radioprotective Properties of Isobornylphenols during X-Ray Irradiation at a Low Dose

Аннотация

The inhibitory efficiency and radioprotective properties of two isobornylphenols were studied during their administration 30 minutes before X-ray irradiation of outbreed mice (females) at a dose of 50 sGy. It was found that 1,3-dihydroxy-4,6-diisopropylbenzene exhibited high efficiency due to its interaction with peroxy radicals. The spleen index and the content of the lipid peroxidation products in blood plasma, which were previously suggested as tests for the assessment of the radioprotective properties of substances during the irradiation of animals at low doses, returned to the norm with the prophylactic administration of 2-isobornyloxyphenols. An aqueous solution of ethanol was found to be unfavorable as a solvent for the administration of hydrophobic substances under the effects of weak radiation. The data we obtained and the literature analysis allow us to propose isobornylphenols as radioprotective agents during radiation at different doses.