The influence of dipyridamole and its derivatives on the membrane energization state of Rhodobacter sphaeroides bacterial chromatophores

Resumo

The mechanisms of the specific influence of dipyridamole therapy remain as a subject of research. In the present work the effects of dipyridamole and some its derivatives on the energization state of photosynthetic membranes of purple bacteria chromatophores have been studied. It was shown that under illumination of chromatophores in the presence of dipyridamole the occurrence of its radical form was observed due to the presence of electron-proton donation properties. These properties are vital to trigger the energization of a functionally active photosynthetic membrane when it is illuminated in the presence of dipyridamole and its derivatives. It is obvious that these properties of dipyridamole should be taken into account while studying the effects of this agent as a medical preparation with specific action.