The protective effects of antithrombin DNA aptamers in rhabdomyolysis

Resumo

Experiments with white rats were carried out to study the effects of original antithrombin DNA aptamers on the renal function and animal survival in rhabdomyolisis caused by intramuscular injection of a hyperosmolar glycerol solution. The DNA aptamers were demonstrated to exert a nephroprotective effect, reducing a retention azotemia and proteinuria, and improving the renal excretory function and overall survival of animals.