Dephosphorylation of AMP-activated protein kinase in a postural muscle: A key signaling event on the first day of functional unloading
- Авторлар: Vilchinskaya N.A.1, Mochalova E.P.1, Belova S.P.1, Shenkman B.S.1
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Мекемелер:
- Institute of Biomedical Problems
- Шығарылым: Том 61, № 6 (2016)
- Беттер: 1019-1025
- Бөлім: Complex Systems Biophysics
- URL: https://ogarev-online.ru/0006-3509/article/view/152193
- DOI: https://doi.org/10.1134/S0006350916060269
- ID: 152193
Дәйексөз келтіру
Аннотация
The AMP analog 5-aminoimidazole-4-carboxamide ribofuranoside (AICAR), which acts as an AMP-activated protein kinase (AMPK) activator, was used to study the signal effects of AMPK dephosphorylation. AMPK activation was found to prevent an increase in phosphor-p70S6K after 24 h of gravitational unloading. Pretreatment with AICAR abolished an increase in the expression of the slow myosin pre-mRNA and mature mRNA and myosin heavy chain IIA mRNA in soleus muscle fibers of rats after short-term gravitational unloading. The finding was taken to indicate that a decrease in phosphorylated AMPK under unloading is an important factor in downregulating expression of slow myosin and myosin IIA.
Негізгі сөздер
Авторлар туралы
N. Vilchinskaya
Institute of Biomedical Problems
Хат алмасуға жауапты Автор.
Email: vilchinskaya2008@rambler.ru
Ресей, Khoroshevskoe sh. 76a, Moscow, 123007
E. Mochalova
Institute of Biomedical Problems
Email: vilchinskaya2008@rambler.ru
Ресей, Khoroshevskoe sh. 76a, Moscow, 123007
S. Belova
Institute of Biomedical Problems
Email: vilchinskaya2008@rambler.ru
Ресей, Khoroshevskoe sh. 76a, Moscow, 123007
B. Shenkman
Institute of Biomedical Problems
Email: vilchinskaya2008@rambler.ru
Ресей, Khoroshevskoe sh. 76a, Moscow, 123007
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