Dephosphorylation of AMP-activated protein kinase in a postural muscle: A key signaling event on the first day of functional unloading


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Аннотация

The AMP analog 5-aminoimidazole-4-carboxamide ribofuranoside (AICAR), which acts as an AMP-activated protein kinase (AMPK) activator, was used to study the signal effects of AMPK dephosphorylation. AMPK activation was found to prevent an increase in phosphor-p70S6K after 24 h of gravitational unloading. Pretreatment with AICAR abolished an increase in the expression of the slow myosin pre-mRNA and mature mRNA and myosin heavy chain IIA mRNA in soleus muscle fibers of rats after short-term gravitational unloading. The finding was taken to indicate that a decrease in phosphorylated AMPK under unloading is an important factor in downregulating expression of slow myosin and myosin IIA.

Авторлар туралы

N. Vilchinskaya

Institute of Biomedical Problems

Хат алмасуға жауапты Автор.
Email: vilchinskaya2008@rambler.ru
Ресей, Khoroshevskoe sh. 76a, Moscow, 123007

E. Mochalova

Institute of Biomedical Problems

Email: vilchinskaya2008@rambler.ru
Ресей, Khoroshevskoe sh. 76a, Moscow, 123007

S. Belova

Institute of Biomedical Problems

Email: vilchinskaya2008@rambler.ru
Ресей, Khoroshevskoe sh. 76a, Moscow, 123007

B. Shenkman

Institute of Biomedical Problems

Email: vilchinskaya2008@rambler.ru
Ресей, Khoroshevskoe sh. 76a, Moscow, 123007

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