The Antitumor Activity of Dinitrosyl Iron Complexes with Mercaptosuccinate in Murine Solid Tumor Models

A. F. Vanin; L. A. Ostrovskaya; D. B. Korman; N. V. Bluchterova; V. A. Rykova; M. M. Fomina

doi:10.1134/S0006350919060228

The Antitumor Activity of Dinitrosyl Iron Complexes with Mercaptosuccinate in Murine Solid Tumor Models

Authors: Vanin A.F.¹^,2, Ostrovskaya L.A.³, Korman D.B.³, Bluchterova N.V.³, Rykova V.A.³, Fomina M.M.³
Affiliations:
1. Semenov Institute of Chemical Physics, Russian Academy of Sciences
2. Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
3. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Issue: Vol 64, No 6 (2019)
Pages: 999-1002
Section: Complex Systems Biophysics
URL: https://ogarev-online.ru/0006-3509/article/view/153162
DOI: https://doi.org/10.1134/S0006350919060228
ID: 153162

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Abstract
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Abstract

The antitumor activity of the binuclear form of dinitrosyl iron complexes with mercaptosuccinate administered intravenously was studied in murine models of solid tumors: Lewis lung carcinoma and Acatol adenocarcinoma. The maximum effect, suppression of tumor growth by 65% in comparison to the control for Lewis carcinoma, was observed for a course of six intravenous injections in a daily dose of 2.5 μM/kg administered every 2 or 3 days over the period of days 1–17 after tumor transplantation.

Keywords

nitric oxide, dinitrosyl iron complexes, murine solid tumor models, Lewis lung carcinoma, Acatol adenocarcinoma, intravenous administration

About the authors

A. F. Vanin

Semenov Institute of Chemical Physics, Russian Academy of Sciences; Institute of Regenerative Medicine, Sechenov First Moscow State Medical University

Author for correspondence.
Email: vanin@polymer.chph.ras.ru
Russian Federation, Moscow, 119334; Moscow, 119991