The Cytotoxicity of Cold Atmospheric Plasma against HeLa Cancer Cells and its Modification with Pharmaceutical Substances

A. G. Akopdzhanov; N. L. Shimanovskii; D. S. Stepanova; T. A. Fedotcheva; A. V. Pulish; N. G. Gusein-zade; L. V. Kolik; E. M. Konchekov

doi:10.1134/S0006350919060034

The Cytotoxicity of Cold Atmospheric Plasma against HeLa Cancer Cells and its Modification with Pharmaceutical Substances

Authors: Akopdzhanov A.G.¹, Shimanovskii N.L.¹, Stepanova D.S.¹, Fedotcheva T.A.¹, Pulish A.V.¹, Gusein-zade N.G.¹^,2, Kolik L.V.¹^,2, Konchekov E.M.¹^,2
Affiliations:
1. Pirogov Russian National Research Medical University
2. Prokhorov General Physics Institute, Russian Academy of Sciences
Issue: Vol 64, No 6 (2019)
Pages: 926-929
Section: Cell Biophysics
URL: https://ogarev-online.ru/0006-3509/article/view/153146
DOI: https://doi.org/10.1134/S0006350919060034
ID: 153146

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Abstract

It has been shown that low-temperature non-equilibrium piezoelectric direct discharge plasma exerts a dose-dependent cytotoxic effect on a HeLa cell culture. Doxorubicin, an antitumor antibiotic, potentiates this effect of cold plasma, while dihydroquercetin, as an antioxidant, attenuates it.