Amelioration of Rhabdomyolysis-Induced Acute Kidney Injury by Ademetionine

Abstract

Abstract—Using the animal model of rhabdomyolysis-induced acute kidney injury have revealed a significant nephroprotective effect of ademetionine by ability to eliminate the toxic action of myoglobin, manifested by an increase in diuresis, and glomerular filtration rate, a reduction of retention azotemia and proteinuria, the normalization of ion-regulating kidney function, an activation of the glomerular–tubular and tubular–tubular balances, and an improvement energy supply to the kidneys. A significant antioxidant effect of ademetionine has been confirmed with evidence that catalase and glutathione peroxidase activities were increased in kidney tissue with a significant decrease in lipid peroxidation and protein degradation. A cytoprotective efficacy was proven due to a decrease in gamma glutamyl transpeptidase activity in the urine of experimental animals.