Email this article Activation of Sarcolemmal α2 Adrenoceptors Supports Са2+ Homeostasis and Prevents Ventricular Arrhythmia under Sympathetic Stress
- Authors: Averin A.S.1, Nakipova O.V.1, Kosarsky L.S.1, Pimenov O.Y.2, Galimova M.H.2, Nenov M.N.2,3, Berejnov A.V.1, Alekseev A.E.2,4
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Affiliations:
- Institute of Cell Biophysics, Russian Academy of Sciences
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- Alzheimer’s Center at Temple, Lewis Katz School of Medicine, Temple University
- Department of Cardiovascular Medicine, Center for Regenerative Medicine, Stabile 5, Mayo Clinic
- Issue: Vol 64, No 5 (2019)
- Pages: 793-798
- Section: Complex Systems Biophysics
- URL: https://ogarev-online.ru/0006-3509/article/view/153086
- DOI: https://doi.org/10.1134/S0006350919050014
- ID: 153086
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Abstract
Abstract—The body’s response to stress is mediated by the interaction of catecholamines with adrenergic α- and β-receptors. It has been established that, in contrast to α1- and β-adrenoceptors, α2-adrenoceptors are involved in feedback loops of the simpatoadrenal system, which controls the release of catecholamines (norepinephrine and epinephrine) to save energy resources and the function of peripheral organs under an overload of catecholamines. Violations of the feedback mechanisms lead to various pathologies, including hypertrophic heart remodeling, followed by the development of heart failure. We previously found the expression of α2-adrenoreceptors in the plasma membrane of cardiomyocytes, where they participate in the regulation of the intracellular level of Ca2+. We suggested that these receptors are able to locally control the response of the heart muscle to stress in addition to the traditional mechanism. We have shown in this study that sarcolemmal α2-adrenoreceptors attenuate the positive inotropic effect of adrenergic stimulation in papillary muscles by controlling the level of free Ca2+ in cytosol. The ability of α2-adrenoreceptor agonists to suppress intracellular spontaneous Ca2+ oscillations increases the efficiency of systolic function of papillary muscles and reduces the likelihood of dangerous ventricular arrhythmia. Thus, α2-adrenoreceptors in the sarcolemmal membrane of cardiomyocytes have their own protective potential, which can prevent pathological remodeling of the heart muscle under chronic stress.
About the authors
A. S. Averin
Institute of Cell Biophysics, Russian Academy of Sciences
Author for correspondence.
Email: averinas82@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
O. V. Nakipova
Institute of Cell Biophysics, Russian Academy of Sciences
Email: averinas82@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
L. S. Kosarsky
Institute of Cell Biophysics, Russian Academy of Sciences
Email: averinas82@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
O. Yu. Pimenov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: averinas82@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
M. H. Galimova
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: averinas82@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
M. N. Nenov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; Alzheimer’s Center at Temple, Lewis Katz School of Medicine, Temple University
Email: averinas82@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290; Philadelphia, PA, 19140
A. V. Berejnov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: averinas82@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290
A. E. Alekseev
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences; Department of Cardiovascular Medicine, Center for Regenerative Medicine,Stabile 5, Mayo Clinic
Email: averinas82@gmail.com
Russian Federation, Pushchino, Moscow oblast, 142290; Rochester, MN
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