Monocyte-Macrophage Differentiation Suppresses the Expression of Proapoptotic Receptors to Apo2L/TRAIL and Increases Resistance to TRAIL-Induced Apoptosis

Abstract

Abstract—A comparative study of the expression of pro- and anti-apoptotic receptors to cytokine TRAIL (TNF-related apoptosis-inducing ligand) on immature blast cells of acute myeloid leukemia, on the cells of acute myeloid leukemia differentiated into monocyte-like and macrophage-like cells, and on normal monocytes and macrophages has been performed. It has been shown that a decrease in the expression of proapoptotic receptors to TRAIL and the acquisition of resistance to TRAIL-induced apoptosis occurs not only during the differentiation of acute myeloid leukemia cells into monocyte-like and macrophage-like cells, but also during the maturation of normal monocytes into macrophages. Thus, the differentiation of both acute myeloid leukemia cells and normal myeloid cells in the direction of monocyte-macrophages mediates a decrease in the expression of proapoptotic receptors to TRAIL, which in turn can determine the resistance of normal myeloid cells to TRAIL-induced apoptosis.