The Impact of Stochastic Perturbations upon the Hydrodynamic Relationship between the Activity of Human Cardiac Ventricles and Low-Frequency Blood Flow Oscillations in the Microcirculatory Bed

Abstract

Abstract—The experimentally revealed high phase coherence between low-frequency oscillations in the cutaneous blood perfusion signal at the contralateral skin sites indicates the existence of a central mechanism of its regulation. The vascular bed can be such a regulatory mechanism because it is a closed hydrodynamic system. It has been shown in this study using a mathematical model of the human cardiovascular system that the impact of low-intensity stochastic perturbations on the stiffness of the cardiac ventricles leads to the formation of low-frequency oscillations in microvascular blood flow. The results show that there is a relationship between the activity of the heart and low-frequency oscillations of microcirculatory skin blood flow, which is due to the hydrodynamic properties of the vascular bed without the involvement of autonomous control from autonomic nervous system.