The Resistance of Multipotent Mesenchymal Stromal Cells to the Effect of Glucose Deprivation under Conditions of a Reduced Oxygen Content

Abstract

It was demonstrated, that glucose deprivation in combination with a decreased oxygen (down to 1%) contributes to support of on multipotent mesenchymal stromal cell viability and suppresses the generation of intracellular reactive oxygen species. The support of of on multipotent mesenchymal stromal cell viability of multipotent mesenchymal stromal cells under these conditions may be due to the transient increase of HIF-1α transcription factor induced by hypoxia. It was accompanied by upregulation of HIF1-target genes, encoded key enzymes of glycolysis.