The State of Glutathione in Animal Blood Plasma in the Development of Experimental Pathology that Simulates Neurodegeneration of the Alzheimer’s Disease Type

Abstract

The study of glutathione in the blood plasma of NMR1 mice during the development of a pathology that simulates neurodegeneration caused by removal of the olfactory bulbs (bulbectomy) was carried out in comparison with sham-operated (not subjected to the removal of the olfactory bulbs) and control (before surgery) animals. At 1 month after surgery, a twofold increase in the levels of reduced and oxidized glutathione was detected and an increase in the thiol/disulfide ratio in the blood plasma of bulbectomized mice relative to sham-operated animals was observed. A decrease in the thiol/disulfide ratio as a result of depletion of reduced glutathione and accumulation of oxidized glutathione in animal blood plasma was observed during the period from 3 to 12 months, which is a sign of a pathological process. The major disorders related to oxidative stress were revealed during the maximum manifestation of the disease. During this period, a significant decrease in the reducing capacity of cellular redox pairs, such as reduced glutathione/glutathione disulphide was observed.