Mass Spectrometric Analysis of the Antinociceptive Effect of Lidocaine

Abstract

Relative measurements of the concentration of CO₂ released through the skin in rats in response to thermal stimulation were performed using a mass spectrometer with a membrane interface. It is demonstrated that the antinociceptive response to a pain stimulus during intraperitoneal propofol–lidocaine and propofol–ketamine anesthesia can be monitored using a mass spectrometer with a membrane interface. Lidocaine exerts direct action on the central nervous system and induces an antinociceptive effect in response to thermal stimulation.