The systems biology of signaling pathways

Abstract

Signaling networks play the central role in the regulation of processes in a single cell and in the entire body. A recent breakthrough in technologies for systems biology, which combine experimental and mathematical methods, permits scientists to model signaling pathways in an individual cell and in cell populations. This approach provides new information on mechanisms that regulate a variety of biological processes. Here we discuss the mathematical formalisms that are applied to signaling pathway modeling and relevant experimental methods.