Effects of Nanosize Coatings Consisting of Two-Dimensionally Ordered Linear Chain Carbon on the Microbial Colonization of Bioprostheses

Resumo

Creation of nanosize coatings from two-dimensionally ordered linear chain carbon (TDOLCC) on the surfaces of biological heart valve prostheses had no significant influence on the adhesion of clinical strains of microorganisms. However, studies of the viability of test cultures on modified biotissue surfaces showed that adherent staphylococcal cultures did not retain viability, with the exception of Staphylococcus saprophyticus. Viability results for Gram-negative cultures varied: from the absence of growth in the case of Klebsiella pneumoniae on biotissues with TDOLCC to continuous growth of strains of Pseudomonas aeruginosa and Acetinobacter baumannii on the same surfaces. Doping of TDOLCC coatings with nitrogen prevented test culture adhesion and colonization (except for Candida albicans) after artificial inoculation of modified bioprostheses with clinical strains of microorganism